Ansgar Santel Selected Research

Atu027

12/2014	First-in-human phase I study of the liposomal RNA interference therapeutic Atu027 in patients with advanced solid tumors.
1/2012	Phase I clinical development of Atu027, a siRNA formulation targeting PKN3 in patients with advanced solid tumors.
11/2010	Atu027 prevents pulmonary metastasis in experimental and spontaneous mouse metastasis models.
12/2008	Atu027, a liposomal small interfering RNA formulation targeting protein kinase N3, inhibits cancer progression.

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Ansgar Santel Research Topics

Disease

6	Neoplasms (Cancer) 12/2014 - 08/2004
4	Inflammation (Inflammations) 01/2018 - 08/2010
3	Sepsis (Septicemia) 01/2018 - 10/2014
2	Neoplasm Metastasis (Metastasis) 12/2014 - 11/2010
2	Lymphatic Metastasis 11/2010 - 12/2008
2	Prostatic Neoplasms (Prostate Cancer) 11/2010 - 11/2003
1	Pneumococcal Pneumonia 01/2018
1	Pneumonia (Pneumonitis) 01/2018
1	Bacterial Pneumonia 01/2018
1	Infections 03/2016
1	Hypertension (High Blood Pressure) 10/2014
1	Respiratory Insufficiency (Respiratory Failure) 12/2010
1	Ventilator-Induced Lung Injury 12/2010
1	Neoplasm Micrometastasis 11/2010
1	Lewis Lung Carcinoma 11/2010
1	Vascular Diseases (Vascular Disease) 09/2010
1	Pancreatic Neoplasms (Pancreatic Cancer) 12/2008

Drug/Important Bio-Agent (IBA)

7	Small Interfering RNA (siRNA)IBA 10/2014 - 11/2003
4	Atu027IBA 12/2014 - 12/2008
3	Angiopoietin-2IBA 01/2018 - 10/2014
3	Proteins (Proteins, Gene)FDA Link 07/2015 - 05/2008
2	Pharmaceutical PreparationsIBA 07/2015 - 11/2010
1	Streptococcus pneumoniae plY proteinIBA 01/2018
1	AngiopoietinsIBA 01/2018
1	Angiopoietin-1IBA 01/2018
1	Phosphotransferases (Kinase)IBA 03/2016
1	TIE-2 Receptor (Receptor, TIE 2)IBA 03/2016
1	LigandsIBA 03/2016
1	Oxidoreductases (Dehydrogenase)IBA 07/2015
1	Therapeutic UsesIBA 12/2014
1	LipopolysaccharidesIBA 10/2014
1	Oxygen (Dioxygen)IBA 12/2010
1	AdrenomedullinIBA 12/2010
1	cadherin 5IBA 11/2010
1	protein kinase NIBA 12/2008
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 05/2008
1	Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA 11/2003

Therapy/Procedure

4	Therapeutics 01/2018 - 11/2010
1	Length of Stay 01/2018
1	Premedication 12/2014
1	Intravenous Infusions 12/2014
1	Ligation 10/2014
1	Punctures 10/2014
1	Mechanical Ventilators (Ventilator) 12/2010
1	Artificial Respiration (Mechanical Ventilation) 12/2010
1	Intravenous Administration 11/2010
1	RNAi Therapeutics 09/2010